Brunner Gland Adenoma Masquerading as Duodenal Gastrointestinal Stromal Tumor with Intussusception: Case Report

Brunner gland adenoma (Brunerroma or hamartoma) is a rare, benign lesion of the Brunner’s glands, accounting for 10.6% of benign duodenal tumors10. It is predominantly seen in the 5th to 6th decades and with no gender predilection13. It is often an incidental finding during esophagogastroduodenoscopy or imaging studies. In symptomatic patients, clinical manifestations include gastrointestinal bleeding, duodenal obstruction, abdominal pain, ampullary obstruction, or intussusception8,9. Given their potential to be mistaken as cancer, it is important to consider it in the differential diagnosis of duodenal masses14. As there have been reports of focal cellular atypia and adenocarcinoma within the lesion, resection, whether endoscopic or surgical is recommended for suspected Brunneromas3. We report here a case of Brunneroma, which presented as gastrointestinal stromal tumor (GIST) with intussusception on radiological and endoscopic studies and brief review of literature.